Phytochemical and pharmacological investigation of the plant ocimum basilicum with special reference to its anti ulceration property

Objective: The plant Ocimum basilicum belonging to family Lamiaceae is used in Skin disease, eye disease, fever and wounds. The present study was carried out to evaluate the effect of Ocimum basilicum whole plant (ethanolic and aqueous extract p.o.) on gastric and duodenal ulceration. Materials and Methods: The study was carried out on duodenal ulceration models such as cysteamine induced ulceration. The duodenal ulcers were induced by using Cysteamine hydrochloride. Ranitidine (20 mg/kg) was used as standard drug.Results Both the extracts of the plant Ocimum basilicum produced significant activity in Cysteamine induced duodenal ulceration. The aqueous extract showed potent activity than ethanolic extract.Conclusion: The plant Ocimum basilicum Linn. Increases healing of gastric ulceration and prevents the development of experimentally induced gastric and duodenal ulceration in rats.